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Analysis of Causes of Glass Packaging Breakage in Lyophilized Preparations
- Categories:Industry Dynamic
- Author:
- Origin:
- Time of issue:2025-03-24 17:00
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(Summary description)
Analysis of Causes of Glass Packaging Breakage in Lyophilized Preparations
(Summary description)
- Categories:Industry Dynamic
- Author:
- Origin:
- Time of issue:2025-03-24 17:00
- Views:
The characteristics of freeze-dried formulations mean that the glass packaging material undergoes thermal shock, while the internal formulation experiences cooling and expansion. Therefore, the cracking during the freeze-drying process can be attributed to several possible reasons:
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Process and Design of Glass Packaging Material: Sometimes, the entire bottom of the bottle may fall off, which could be related to insufficient annealing of the bottle, making the bottom edge too fragile.
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Formulation-Related Issues: Certain special components in the formulation may be prone to causing excessive expansion.
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Fill Volume: Overfilling the container may not leave enough space for expansion during the freeze-drying process.
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Local Defects in the Glass Packaging During the Manufacturing Process: These defects can act as the "last straw" that causes the container to break, serving as the starting point for the rupture.
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